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Tweedy Browne decreased ISI position by 436,286 shares

Mar 28, 2026Last updated Jul 9, 2026

This StonkWhisper whale intelligence report documents significant institutional position changes in $ISI based on SEC 13F filings and block-level trading data. Quarterly 13F disclosures are required for institutional investment managers with at least $100 million in qualifying assets under management. These filings reveal long positions in U.S. equities held as of quarter end. Material changes in institutional positioning — particularly from concentrated funds with a history of high-conviction bets — are tracked by StonkWhisper as leading indicators of institutional thesis formation or exit.

Tweedy, Browne Co LLC AUM: $1.3B DECREASED

AUM: $1.3B · 93 holdings · Period: 2025-12-31

436,286 Share Change

2,464,930 Current Shares

$195.0B Current Value

15.74% Portfolio %

-15.0% Change %

Position Change Detail

Issuer IONIS PHARMACEUTICALS INC.

Ticker ISI

Shares 2,901,216 → 2,464,930 436,286

Value $189.8B → $195.0B

Portfolio Weight 15.74%

Change Type Decreased

Period of Report 2025-12-31

Other Tweedy Browne Positions This Period

Ticker	Issuer	Change Type	Share Change	Value
FMC	FMC CORP.	Decreased	203,750	$279.5M
TTEN	TOTALENERGIES SE ADR	Exited	132,189	—
UNF	UNIFIRST CORP	New	+102,059	$19.7B
ATMU	ATMUS FILTRATION TECHNOLOGIES	Decreased	48,607	$2.1B
CVE	CENOVUS ENERGY	Exited	46,942	—
GOOGL	ALPHABET INC-CL A	Decreased	34,406	$62.5B
ALV	AUTOLIV INC.	Decreased	31,740	$47.6B
PSEC	PROSPECT CAPITAL CORP	Increased	+23,331	$422.0M
WFC	WELLS FARGO & CO	Decreased	22,228	$52.1B
TAP	MOLSON COORS BREWING COMPANY	New	+20,167	$941.4M

Other Whales Moving ISI This Period

Manager	Change Type	Share Change
Capital World	Increased	+5,238,571
Franklin Templeton	Increased	+1,314,709
Adage Capital	Decreased	1,175,000
Two Sigma	Increased	+1,082,703
Millennium	Decreased	686,308
Balyasny	Decreased	499,511
Arrowstreet	Increased	+433,191
State Street	Decreased	413,786
DE Shaw	Decreased	295,692
Artisan Partners	Increased	+291,344

View all sentiment, news, and whale activity for ISI (IONIS PHARMACEUTICALS INC.).

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Data sourced from SEC 13F institutional holdings filings. This page does not constitute financial advice. StonkWhisper presents public records — it does not verify or guarantee the accuracy of institutional filings. 13F filings are reported quarterly and may lag actual positions.

Last updated: July 09, 2026 at 06:01 UTC